hif-2α glutathione The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancer: Molecular Cell sold-out-one-location

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48,49,50,51 Moreover, through the action of two of the enzymes involved in the production of H 2 S—cysteine aminotransferase (CAT) and 3-mercaptopyruvate sulphurtransferase (3-MST)—cysteine is sequentially converted into 3-mercaptopyruvate (3-MP) with the release of an amino group that will react with α-ketoglutarate, ending with the formation of glutamate and pyruvate (Fig