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Furthermore, the interaction of ACTL6A with GCLC promoter was weakened by NRF2 KD, and likewise, the interaction of NRF2 with GCLC promoter was weakened by ACTL6A KD (Fig
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In eukaryotes, control of heme synthesis occurs primarily at its rate-limiting enzyme, delta-aminolevulinate synthase (encoded by ubiquitously expressed ALAS1 and erythroid-restricted ALAS2)
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