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For example, 6-OHDA does not pass the blood–brain barrier (BBB) and must be injected directly in the brain area or given intraventricularly to produce the lesion.[30] The lesions are produced rapidly when the agent is injected into the substantia nigra, usually within hours to a few days, and only produce progressive neurodegeneration when it is injected intrastriatal and then develop much faster than is seen clinically, usually within 1–3 weeks

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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Caffrey E.B., Perelman D., Ward C.P., Sonnenburg E.D., Gardner C.D., Sonnenburg J.L