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The use of Aβ42H13L (TABLE 1), in which one of the adjacent His residues was replaced by Leu, a substitution that would preclude any bidentate Cu 2+ ligand binding, led to results consistent with the notion that bidentate Cu 2+ ligand binding of these His residues was not essential for the oxidative damage and cellular toxicity of the native peptide (115)

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[DOI] [PubMed] [Google Scholar] 72.Yen C.-W., Kuhn R., Hu C., Zhang W., Chiang P.-C., Chen J.Z., Hau J., Estevez A., Nagapudi K., Leung D.H