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For example, one Scientific Reports study of the NNMT inhibitor JBSNF-000088 reported micromolar-range inhibition of human, monkey, and mouse NNMT in fluorescence-based biochemical assays (IC 50 values approximately 1.8, 2.8, and 5.0 µM, respectively) and confirmed human NNMT inhibition with an LC-MS/MS detection method
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34 Additionally, these metabolites interfere with pancreatic juice secretion by increasing protein precipitation and facilitating protein plug formation within the pancreatic ducts
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