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PDF) Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications
The mitogen-activated protein kinase (MAPK), nuclear factor kappa-B (NF-κB), transforming growth factor beta 1/smad proteins (TGF-β1/Smad), and nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) signaling pathways also have effects on skin aging ( Figure 1 Increased levels of oxidative stress that lead to skin aging occur as a result of nitrogen oxides such as polycyclic aromatic hydrocarbons (PAH), nitric oxide (NO), nitrojen dioksit (NO 2 ), and ozone (O 3 ) formed by environmental pollution
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