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However, the full pleiotropic complexity of the lidocaine-induced convulsion illustrates the various systems implicated (i.e., the NMDA and non-NMDA receptors systems, NO-system, serotonin, GABA, dopamine, and noradrenaline) [56–61]
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Conversely, Rhein was found to inhibit ferroptosis and epithelial‒mesenchymal transition by modulating the RAC1/NOX1/beta-catenin axis, thus mitigating diabetic nephropathy [134]
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