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Fifth, redesign trials as mechanism-anchored: use biomarker gates for enrollment and co-primary endpoints that pair mechanistic change (e.g., Prx cycling, 2-OH-E⁺, LIP shifts) with clinical benefit, avoiding the trap of “ROS lowering without outcome” (Drakulic et al Flavor:Absinthium GHK-CU - Dakota Peptology http://skinspanewyork.com/cdn/shop/products/b12-3.jpg?v=1762553092 كريم يحد من تراكم الميلانين
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